Sermorelin for injection is available in multidose vials containing sufficient product for 15 days of therapy. Each vial contains from 3 to 7.5 milligrams of Sermorlin as a sterile, lyophilized powder. Sufficient diluent (3 ml sterile, isotonic saline) is provided so that each 0.2 milliliter of the reconstituted solution contains daily doses ranging from 200 to 500 micrograms Sermorelin. Recommended doses include the following:

3 mg MDV: 200 ug/day for men with BMI from 18.5 – 24.9

4.5 mg MDV: 300 ug/day for men with BMI between 25 and 29.9

6 mg MDV: 400 ug/day for women or for men with BMI between 25 and 29.9

7.5 mg MDV: 500ug/day for women or for men with BMI between 25 and 29.9

These recommended dosages are based upon the results of clinical testing in men of normal weight in whom 200ug/day increased pituitary reserve of hGH (as indicated by enhanced responses to provocative testing) and increased IGF-1. A sample set of the latter data are provided in the following table. IGF-1 increased in men ranging in age from 50 to 66 years after 30 consecutive days sc administration of 200 ug Sermorelin..

Since estrogen and adiposity negatively effect growth hormone action on the liver to produce IGF-1, higher doses of Sermorelin are recommended for women and men with high BMIs.